JSM Preliminary Online Program
This is the preliminary program for the 2009 Joint Statistical Meetings in Washington, DC.

The views expressed here are those of the individual authors
and not necessarily those of the ASA or its board, officers, or staff.

Back to main JSM 2009 Program page

Activity Number: 362
Type: Topic Contributed
Date/Time: Tuesday, August 4, 2009 : 2:00 PM to 3:50 PM
Sponsor: Section on Statistics in Epidemiology
Abstract - #305733
Title: Computational Intelligence-Based Data Mining for the Minimal Clinically Relevant Difference in the Unified Parkinson's Disease Rating Scale
Author(s): Nitzan Mekel-Bobrov*+
Companies: Boston Scientific Corporation
Address: 25155 Rye Canyon Loop, Valencia, CA, 91355,
Keywords: Mining ; Parkinson's ; UPDRS ; MCRD ; MCID
Abstract:

The Unified Parkinson's Disease Rating Scale (UPDRS) is currently the gold standard in rating the symptoms of patients with Parkinson's disease (PD) for clinical, research, and regulatory purposes. A major difficulty, however, is the lack of a robust definition for a minimal clinically relevant difference (MCRD) in UPDRS scores. Quantification of this parameter would offer many advantages in designing and analyzing clinical trials. This paper presents a data mining method, based on a computational intelligence framework, for estimating the MCRD of a health outcome score. Using previously published clinical trial data, this method is then applied to the Unified Parkinson's Disease Rating Scale to establish a clinically significant change in PD patient response to medical intervention.

  • The address information is for the authors that have a + after their name.
  • Authors who are presenting talks have a * after their name.

Back to the full JSM 2009 program


JSM 2009 For information, contact jsm@amstat.org or phone (888) 231-3473. If you have questions about the Continuing Education program, please contact the Education Department.
Revised September, 2008