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Activity Number: 76
Type: Contributed
Date/Time: Sunday, August 2, 2009 : 4:00 PM to 5:50 PM
Sponsor: Section on Bayesian Statistical Science
Abstract - #305666
Title: Dose-Finding in Phase I Clinical Trials with Logistic Joinpoint Regression
Author(s): Ling Lan*+ and Grzegorz A. Rempala
Companies: Medical College of Georgia and Medical College of Georgia
Address: 1120 15th Street, Augusta, GA, 30912,
Keywords: Phase I clinical trial ; Bayesian logistic joinpoint regression ; p-spline ; Dose finding
Abstract:

We propose an extension of Bayesian logistic joinpoint regression model to design of Phase I clinical trials. We discuss the calculation of the unknown join points in the model corresponding to the individualized test doses. A numerical simulation shows the efficacy of the new approach in comparison with the traditional 3+3 design, CRM and other Bayesian models. The method is illustrated in a dose finding trial.

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