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Activity Number:
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73
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Type:
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Contributed
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Date/Time:
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Sunday, August 2, 2009 : 4:00 PM to 5:50 PM
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Sponsor:
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Section on Risk Analysis
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| Abstract - #305628 |
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Title:
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On the Identifiability Issues in Physiologically-Based Toxicokinetics (PBTK) Models
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Author(s):
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Munni Begum*+
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Companies:
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Ball State University
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Address:
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Department of Mathematical Sciences, Muncie, IN, 47306,
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Keywords:
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PBTK models ; Identifiability ; Estimability ; Risk assessment ; Extrapolation ; Bayesian estimability
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Abstract:
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PBTK models are now the cornerstone of environmental risk and safety assessment studies. These models are used to estimate internal target organ dosimetry, and can provide the basis for extrapolating between species, doses, and exposure routs. The systematic component of a PBTK model is determined as the solution of a system of differential equations and is usually a nonlinear function of the kinetic parameters. For a certain population, biological variation in the kinetic behavior can be captured by putting distributional assumptions on these parameters. Thus a large number of biological and statistical parameters are to be identified while fitting PBTK models to the experimental data. Identifiability of the model parameters allows and insures valid statistical inference. This paper investigates conditions under which a PBTK model can be considered as identifiable.
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- The address information is for the authors that have a + after their name.
- Authors who are presenting talks have a * after their name.
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