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Activity Number: 561
Type: Contributed
Date/Time: Thursday, August 6, 2009 : 8:30 AM to 10:20 AM
Sponsor: Section on Statistics in Epidemiology
Abstract - #305053
Title: Semiparametric Method for Cure Rate Model
Author(s): Feifei Zhou*+
Companies: The University of Hong Kong
Address: , , ,
Keywords: cure rate model ; multiple imputation
Abstract:

Medical and public health research often involve the analysis of possibly right censored data at which subpopulations of individuals highly susceptible to the events while others are assumed to be at much less risk are hypothesized. In this project, a new class of models for the analysis of clustered cured model is proposed. The class of models is able to accommodate data with correlation within cluster and heterogeneity among clusters. This proposed model is a simple extension of the frailty-Cox model with a special distribution for the frailty term. The estimation method is by means of multiple imputation approach to allow further extension of the model to a more complicated correlated structure. The proposed estimation method is shown to be highly satisfactory through numerical simulation. The method is applied to a real life data set.


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