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Activity Number:
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463
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Type:
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Topic Contributed
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Date/Time:
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Wednesday, August 5, 2009 : 10:30 AM to 12:20 PM
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Sponsor:
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Biopharmaceutical Section
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| Abstract - #305028 |
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Title:
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Error in Variable Modeling for QT Correction
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Author(s):
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Bin Cheng*+ and Yi Tsong
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Companies:
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Columbia University and FDA
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Address:
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, , ,
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Keywords:
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Abstract:
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The current approach for QT correction assumes a parametric relationship between QT and heart rate and treats heart rate as a deterministic covariate rather than as a random variable. We propose a flexible correction method based on nonparametric smoothing and measurement error model. Simulation is conducted to compare the proposed method with the existing procedures. Data from several thorough QTc trials are re-analyzed as illustration.
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- The address information is for the authors that have a + after their name.
- Authors who are presenting talks have a * after their name.
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