|
Activity Number:
|
75
|
|
Type:
|
Contributed
|
|
Date/Time:
|
Sunday, August 2, 2009 : 4:00 PM to 5:50 PM
|
|
Sponsor:
|
Section on Health Policy Statistics
|
| Abstract - #304957 |
|
Title:
|
A Model of the Potential Benefit of C-Reactive Protein Measurement in Primary Prevention for Men and Women with Intermediate Risk of Ten-Year First Coronary Heart Disease Events
|
|
Author(s):
|
Rongwei (Rochelle) Fu*+ and Craig Fleming and Michele Freeman and David Buckley and Mark Helfand
|
|
Companies:
|
Oregon Health & Science University and Oregon Health & Science University and Oregon Health & Science University and Oregon Health & Science University and Oregon Health & Science University
|
|
Address:
|
3181 SW Sam Jackson Park Rd., Portland, OR, 97239,
|
|
Keywords:
|
CRP ; risk reclassification
|
|
Abstract:
|
Elevated high-sensitivity C-reactive protein (hsCRP) may be useful in improving risk assessment and directing therapy in primary prevention of coronary heart disease (CHD). We proposed a model to estimate the potential health impact of measuring hsCRP in persons with intermediate (10-20%) 10-year risk of hard CHD events using data from a meta-analysis of cohort studies, and the National Health and Nutrition Examination Survey for 1999 through 2002. We calculated 10-year risk of first hard CHD events based on models before and after adjustment for hsCRP, and estimated the proportions of persons with intermediate risk reclassified as high (>20%) risk given hsCRP. Persons reclassified were assumed to receive more aggressive risk reduction therapy. The results showed that using hsCRP measurements to improve risk assessment and direct therapy may significantly reduce incident CHD events.
|
