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Activity Number:
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407
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Type:
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Topic Contributed
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Date/Time:
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Wednesday, August 5, 2009 : 8:30 AM to 10:20 AM
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Sponsor:
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Section on Physical and Engineering Sciences
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| Abstract - #304690 |
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Title:
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Estimating the Effect of a Time-Dependent Therapy on Residual Restricted Mean Lifetime
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Author(s):
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Douglas E. Schaubel*+ and John D. Kalbfleisch
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Companies:
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University of Michigan and University of Michigan
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Address:
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1420 Washington Hts., Ann Arbor, MI, 48109-2029,
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Keywords:
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case-cohort sampling ; counterfactual ; landmark method ; observational studies ; stratification
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Abstract:
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We develop semiparametric methods to estimate the effect on restricted mean lifetime of a time-dependent treatment. In the data structure of interest, both an experimental and established form of treatment are available; pre- and post-treatment hazards are non-proportional; subjects may experience periods of treatment ineligibility; treatment assignment is not randomized. The proposed methods involve weighting results from stratified proportional hazards models fitted using a generalization of case-cohort sampling. Asymptotic and finite-sample properties of the proposed estimators are evaluated. The proposed methods are applied to data from a national organ transplant registry.
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