|
Activity Number:
|
609
|
|
Type:
|
Contributed
|
|
Date/Time:
|
Thursday, August 6, 2009 : 10:30 AM to 12:20 PM
|
|
Sponsor:
|
Biometrics Section
|
| Abstract - #304598 |
|
Title:
|
Modeling Cancer-Related Epigenetic Changes in DNA Tandem Repeats
|
|
Author(s):
|
Michelle Lacey*+
|
|
Companies:
|
Tulane University
|
|
Address:
|
Department of Mathematics, New Orleans, LA, 70118,
|
|
Keywords:
|
epigenetics ; cancer ; methylation ; markov model ; dependent sites
|
|
Abstract:
|
DNA methylation is essential for the normal development and functioning of organisms, and frequent abnormal increases or decreases in DNA methyl tags are found in most human cancers and contribute to their development. Through hairpin bisulfite technology and Southern blots, methylation patterns in genomic data can be studied on both a local and regional scale. An analysis of cancer-related methylation changes in the tandem repeats Sat2 and NBL2 determined that clusters of sites with identical methylation status were observed with high frequency in samples from both somatic controls and ovarian carcinomas. These findings cannot be explained by existing models for methylation change, and we have therefore developed a neighboring-sites approach which better explains the observed data and provides new perspective on the biological mechanisms governing DNA methylation.
|
- The address information is for the authors that have a + after their name.
- Authors who are presenting talks have a * after their name.
Back to the full JSM 2009 program |
