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Activity Number:
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175
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Type:
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Roundtables
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Date/Time:
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Monday, August 3, 2009 : 12:30 PM to 1:50 PM
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Sponsor:
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Biopharmaceutical Section
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| Abstract - #304588 |
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Title:
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Randomization Strategies in Multicenter Trials
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Author(s):
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Olga M. Kuznetsova*+
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Companies:
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Merck & Co., Inc.
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Address:
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RY34-A316, Rahway , NJ, 07065-0900,
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Keywords:
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center-based randomization ; central randomization ; forced allocation ; balance across centers ; stratified allocation ; incomplete blocks
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Abstract:
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In planning a multicenter trial, the choice between central and center-based randomization is often the tough one. Will center-based randomization provide a good balance in treatment assignments when a large number of permuted blocks on the randomization schedule are left incomplete? Can center-based randomization accommodate other stratification factors? Will stratification surely aggravate the incomplete block problem or could this be helped? Will central randomization require large drug stocks at the sites? Would a small percentage of forced allocations be acceptable? Are there ways of keeping the balance in treatment assignments---overall as well as within each stratum---while limiting the drug supplies at the sites? All these questions as well as possible solutions that combine elements of central and center-based randomization will be discussed at the table.
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- The address information is for the authors that have a + after their name.
- Authors who are presenting talks have a * after their name.
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