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Activity Number: 307
Type: Topic Contributed
Date/Time: Tuesday, August 4, 2009 : 10:30 AM to 12:20 PM
Sponsor: Biopharmaceutical Section
Abstract - #304533
Title: Sensitivity Analysis in Missing Value Imputation to Assess Quantitative Coronary Angiograph Data in Stent Trials
Author(s): Hong Wang*+ and Heather Bai and Joseph Bero
Companies: Boston Scientific Corporation and Boston Scientific Corporation and Boston Scientific Corporation
Address: M1, Marlborough, MA, 01752,
Keywords: sensitivity analysis ; missing data imputation ; bootstrap
Abstract:

Missing data imputation has been increasingly popular in medical device industry. An imputation methodology in quantitative coronary angiograph for a two-arm stent trial is proposed. The process is to impute missing data one at a time using the worst case scenario for all possible cases. Bootstrapping technique is to evaluate the imputation results.

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