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Activity Number:
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526
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Type:
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Contributed
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Date/Time:
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Wednesday, August 5, 2009 : 2:00 PM to 3:50 PM
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Sponsor:
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Biometrics Section
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| Abstract - #304505 |
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Title:
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Testing Biological Processes in Microarray Experiments Using Prespecified Gene Sets
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Author(s):
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Shuyan (Sabrina) Wan*+ and Xiang Yu
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Companies:
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Merck Research Laboratories and Merck Research Laboratories
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Address:
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, , ,
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Keywords:
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Microarrays ; Gene Set Enrichment Analysis ; Correlation Structure
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Abstract:
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Recent developments in statistical methodology have enabled scientists to test pre-specified sets of genes in microarray experiments rather than to assess individual genes. Using a selected set of genes to define a biological process allows one to determine whether that process is regulated in microarray experiments. Oftentimes it is also desirable to test the pre-specified direction of regulation for each gene in the process. We propose methods using gene sets with assumed direction in regulation that are similar to the method described by Efron and Tibshirani (2007) but with some modifications. Different aggregated statistics for the biological process are used and compared. We show through simulation studies that our methods can appropriately take into account the direction of gene regulation and various correlation structures in the gene set and thus are applicable for real practice.
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