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Activity Number: 101
Type: Topic Contributed
Date/Time: Monday, August 3, 2009 : 8:30 AM to 10:20 AM
Sponsor: Biometrics Section
Abstract - #303936
Title: Modeling Brain Pathways Using Functional Path Analysis
Author(s): Martin Lindquist*+
Companies: Columbia University
Address: 1255 amsterdam ave room 1031, New York, NY, 10027,
Keywords: fMRI ; brain ; functional data analysis ; connectivity
Abstract:

Pathways are fundamental properties of brain organization. They provide a means for discovering links between experimental manipulations, brain activity, and psychological/physiological outcomes. In this work we discuss a set of tools for modeling multi-region functional pathways in fMRI. Our approach is based on a simple three-variable path model, which can provide information on whether a region mediates connectivity between two other regions or peripheral measures. This technique provides an extension of current path analysis techniques to the functional data analysis setting. We use functional path analysis to not only test whether the effects of an experimental manipulation (temperature of noxious heat) on reported pain is mediated by activity in the insula, but also determine the timing of this relationship over the course of a trial.


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Revised September, 2008