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Activity Number:
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520
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Type:
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Contributed
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Date/Time:
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Wednesday, August 5, 2009 : 2:00 PM to 3:50 PM
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Sponsor:
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Section on Statistics in Epidemiology
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| Abstract - #303918 |
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Title:
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Haplotype-Based Regression Analysis with Transmitted and Nontransmitted Haplotypes
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Author(s):
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Yung-Hsiang Huang*+
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Companies:
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National Taiwan University
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Address:
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Graduate Institute of Epidemiology, Rm 523, No.17, Xu-Zhou Road, Taipei City, International, , Taiwan
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Keywords:
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family-based association studies ; transmitted/non-transmitted ; conditional logistic regression ; matched case-control design
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Abstract:
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Association analysis using family data can avoid the problem of hidden population stratification. Using genotype data on affected offspring and their parents, tests of association between disease and susceptible allele can be performed. Recent literature indicate that haplotypes can be more powerful and informative than individual markers like SNPs in most situations. In this study we consider haplotypes instead of SNP genotype data for analysis. Based on transmitted and non-transmitted haplotypes, we propose a new haplotype-based association regression analysis. Here we adopt for analysis the haplotype likelihoods to evaluate the uncertainty of transmission and phase. By conditional logistic regression, we can evaluate each haplotype risk specifically. An application of schizophrenia and simulation studies will be considered for illustration.
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- The address information is for the authors that have a + after their name.
- Authors who are presenting talks have a * after their name.
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