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Activity Number:
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102
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Type:
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Topic Contributed
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Date/Time:
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Monday, August 3, 2009 : 8:30 AM to 10:20 AM
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Sponsor:
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Biopharmaceutical Section
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| Abstract - #303882 |
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Title:
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Interim Enrollment Adjustment
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Author(s):
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Valerii V. Fedorov*+ and Frank Mannino
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Companies:
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GlaxoSmithKline and GlaxoSmithKline
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Address:
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1250 S Collegeville Rd, Collegeville, PA, 19426,
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Keywords:
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design clinical trials ; Gamma-Poisson model
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Abstract:
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In the design of large clinical trials the sound selection of the number of centers involved a trial is an optimization problem that depends on uncertain prior information and potential (random) changes during this trial. The interim corrections, for instance, adding new centers helps to mitigate the role of those uncertainties. We address the problem using the Poisson or Gamma-Poisson model for the enrollment process and the Bayesian approach for updating estimators of their parameters.
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