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Activity Number:
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211
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Type:
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Contributed
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Date/Time:
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Monday, August 3, 2009 : 2:00 PM to 3:50 PM
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Sponsor:
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Biopharmaceutical Section
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| Abstract - #303764 |
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Title:
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Married to Mantel-Haenszel? Consider a Minimum-Risk Affair!
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Author(s):
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Devan V. Mehrotra*+
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Companies:
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Merck Research Laboratories
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Address:
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UG1D-44, North Wales, PA, 19454,
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Keywords:
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Mantel-Haenszel test ; Minimum Risk weights ; score test ; treatment by stratum interaction ; Wald test
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Abstract:
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The Mantel-Haenszel test is a popular default for the analysis of stratified trials with binary (success/failure) endpoints. In this talk, we will show that the M-H method has good power properties only under a restrictive assumption that, unfortunately, is often violated in practice. We will review a "minimum risk" (MR) alternative to the MH test and quantify power (and $$$) gains of the MR versus the MH procedure using simulations. A numerical example will be used to reinforce the key message.
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