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Activity Number:
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78
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Type:
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Contributed
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Date/Time:
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Sunday, August 2, 2009 : 4:00 PM to 5:50 PM
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Sponsor:
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Biopharmaceutical Section
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| Abstract - #303541 |
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Title:
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Dose Reduction Profiles for Combination Drug Studies
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Author(s):
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John J. Peterson*+
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Companies:
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GlaxoSmithKline
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Address:
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1250 So. Collegeville Rd, Collegeville, PA, 19426-0989,
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Keywords:
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Synergy ; Minto-White model ; response surface methodology ; antagonism ; oncology ; graphics
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Abstract:
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In combination drug studies, particularly in oncology, it is important to find a combination of drugs that provide good efficacy but with reduced toxicity. This can sometimes be achieved if each drug has a different primary side-effect. This paper proposes "dose reduction profiles" which show what dose combinations are associated with the best dose reductions for each drug in combination relative to the amount of each drug alone needed to obtain the same level of efficacy. A connection with Loewe synergy is also established.
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