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Activity Number:
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79
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Type:
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Contributed
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Date/Time:
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Sunday, August 2, 2009 : 4:00 PM to 5:50 PM
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Sponsor:
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Biopharmaceutical Section
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| Abstract - #303505 |
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Title:
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Combining Multiple Tests in Clinical Trials with Hierarchical Objectives
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Author(s):
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Alexei A. Dmitrienko*+ and Ajit C. Tamhane and Lingyun Liu
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Companies:
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Eli Lilly and Company and Northwestern University and Northwestern University
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Address:
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10913 West 144th St, Overland Park, KS, 66221,
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Keywords:
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Multiple comparisons ; Type I error rate ; Gatekeeping procedures ; Clinical trials
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Abstract:
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This talk introduces a general framework for constructing multiple testing procedures for clinical trials with hierarchical objectives (also known as gatekeeping procedures). Multiple testing problems arising in clinical trials with hierarchical objectives frequently exhibit a complex structure, including multiple families of hypotheses and logical restrictions. The approach proposed in the talk is based on combining multiple tests across families and enables clinical trial sponsors to set up powerful and flexible multiple testing procedures (e.g., multistage procedures based on Hochberg-type tests that account for logical restrictions among the hypotheses of interest). A clinical trial example is used to illustrate the general approach.
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