JSM Preliminary Online Program
This is the preliminary program for the 2009 Joint Statistical Meetings in Washington, DC.

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Activity Number: 481
Type: Roundtables
Date/Time: Wednesday, August 5, 2009 : 12:30 PM to 1:50 PM
Sponsor: Biopharmaceutical Section
Abstract - #303458
Title: Issues and Challenges in Modeling Bioassay Data
Author(s): Jason Liao*+
Companies: Merck Research Laboratories
Address: , , 19486,
Keywords: Bioassay ; Symmetric curve ; Asymmetric curve ; Weight function
Abstract:

Bioanalytical method is a type of in vitro experiment that is typically conducted to measure the effect or activity of a substance or stimulus in a biological system, for estimating the nature, constitution, or potency of a material (or of a response), and it plays a very important role in developing a high quality vaccine and protein products. It is often very challenging to model and select an appropriate dose-repose curve (symmetry vs. asymmetry) and the weighting function for the bioassay analysis. We will discuss the practical and statistical issues and strategies in analyzing bioassay data.

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Revised September, 2008