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Activity Number:
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433
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Type:
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Contributed
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Date/Time:
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Wednesday, August 5, 2009 : 8:30 AM to 10:20 AM
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Sponsor:
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ENAR
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| Abstract - #303368 |
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Title:
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Evaluating the Association Between Red Blood Cell Storage Duration and Prostate Cancer Recurrence
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Author(s):
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Jarrod E. Dalton*+ and Edward J. Mascha and Daniel I. Sessler and Shamgar Ben-Eliyahu and Juan Cata
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Companies:
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Cleveland Clinic Foundation and Cleveland Clinic Foundation and Cleveland Clinic Foundation and Tel Aviv University and Cleveland Clinic Foundation
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Address:
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Department of Quantitative Health Sciences, Cleveland, OH, 44195,
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Keywords:
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survival analysis ; cancer ; analytic approach
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Abstract:
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The goal of our study was to evaluate the relationship between the storage duration (or age) of transfused red blood cell (RBC) units and recurrence-free survival among 1,127 patients undergoing radical retropubic prostatectomy surgery for the treatment of prostate cancer at the Cleveland Clinic between 1998 and 2007. The study of RBC age as a treatment is complicated by the fact that patients may receive multiple units of varying age; furthermore RBC transfusion strategy differs between solely autologous (or self-donated), solely allogeneic (or received from another donor), and some combination of autologous and allogeneic RBC products. The distributional properties of patient-specific unit age vary depending on the transfusion strategy to the extent that each strategy warrants its own unique analytic approaches. We present our analytic approach for assessing this complicated exposure.
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