JSM Preliminary Online Program
This is the preliminary program for the 2009 Joint Statistical Meetings in Washington, DC.

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Activity Number: 581
Type: Invited
Date/Time: Thursday, August 6, 2009 : 10:30 AM to 12:20 PM
Sponsor: ENAR
Abstract - #303215
Title: Targeted Maximum Likelihood Estimation of Individualized Treatment Rule Effects
Author(s): Kelly Moore*+ and Mark J. van der Laan and Ira Tager and Romain Neugebauer
Companies: University of California, Berkeley and University of California, Berkeley and University of California, Berkeley and University of California, Berkeley
Address: Division of Biostatistics, School of Public Health, Berkeley, CA, 94704,
Keywords:
Abstract:

As an example, we consider the effect of decreases in ambient levels of ozone concentration on cardiac related mortalities in the Los Angeles Basin area. This effect is difficult to estimate using conventional approaches to causal inference that define this effect by comparing the mortality risks corresponding to hypothetical scenarios in which all geographical grids in the target population are exposed to a given level of ozone concentration. Such static treatments are highly unrealistic in this case since grids near coastal areas typically do not experience higher levels of ozone. We present targeted maximum likelihood estimators of realistic causal effects and illustrate them with the above application.


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