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Activity Number:
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135
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Type:
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Invited
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Date/Time:
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Monday, August 3, 2009 : 10:30 AM to 12:20 PM
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Sponsor:
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ENAR
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| Abstract - #303210 |
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Title:
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Current Applications of the Hardy-Weinberg Law
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Author(s):
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Bruce Weir*+
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Companies:
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University of Washington
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Address:
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Department of Biostatistics, Seattle, WA, 98195,
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Keywords:
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Abstract:
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The Hardy-Weinberg Law continues to be used in many contexts. In forensic science, independence of alleles would allow allelic frequencies to be multiplied together to estimate DNA profile probabilities. Although appropriate tests continue to be applied and reported in the forensic science literature, a better approach is to recognize the small amount of dependence brought about by evolutionary forces such as population subdivision. Another major application occurs as art of genetic data quality control activities in whole-genome association tests. In this context, with very large numbers of tests it is important to take account of multiple testing issues. The nonuniform behavior of exact-test p-values under the null hypothesis of Hardy-Weinberg Equilibrium also needs to be considered.
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- The address information is for the authors that have a + after their name.
- Authors who are presenting talks have a * after their name.
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