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Activity Number:
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538
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Type:
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Invited
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Date/Time:
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Thursday, August 6, 2009 : 8:30 AM to 10:20 AM
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Sponsor:
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Section on Physical and Engineering Sciences
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| Abstract - #303157 |
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Title:
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Screening Compounds for Monotone Association with Convex Combinations of Activity Predictors Over Unspecified Subpopulations of Cell-Lines
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Author(s):
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Joseph S. Verducci*+ and Li Yu and Paul Blower
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Companies:
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The Ohio State University and The Ohio State University and The Ohio State University
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Address:
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Department of Statistics, Columbus, OH, 43210-1945,
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Keywords:
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Kendall's tau ; partial ordering ; mixture model ; copula ; discovery ; high throughput
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Abstract:
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The tau-path test is a new procedure for finding monotone association between two variables over an unspecified subpopulation. It has been used in conjunction with the NCI-60 panel of cancer cells to associate the biological activity of molecular compounds with gene expression over different types of cancer. In some confirmed examples, the identified subpopulations of cancer cell-lines include those that are estrogen regulated and those that are less differentiated. This talk covers an extension of the method to check for possible association between a response (compound activity) and a convex combination of predictors (mRNA and microRNA expressions).
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