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This is the preliminary program for the 2009 Joint Statistical Meetings in Washington, DC.

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Activity Number: 574
Type: Invited
Date/Time: Thursday, August 6, 2009 : 10:30 AM to 12:20 PM
Sponsor: Biometrics Section
Abstract - #303146
Title: Epigenetic Natural Variation in Arabidopsis Thaliana
Author(s): Robert A. Martienssen*+
Companies: Cold Spring Harbor Laboratory
Address: 1 Bungtown Road, Cold Spring Harbor, NY, 11724,
Keywords:
Abstract:

Epigenetic information is superimposed on genetic information by chemical modifications of the DNA itself and of proteins around which it is wrapped. This information has dramatic effects on the expression of genes and on the heritability of certain traits, both during development and from generation to generation. Microarray and next generation sequencing technologies can gather epigenetic information rapidly, reproducibly and comprehensively, but interpreting the data is challenging from a statistical point of view. Chief among these challenges is the existence of the histone code, whereby combinations of modifications have very different outcomes from any given modification alone. We will use epigenetic variation in the mustard plant Arabidopsis thaliana to illustrate biological issues relevant to these challenges.


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Revised September, 2008