JSM Preliminary Online Program
This is the preliminary program for the 2009 Joint Statistical Meetings in Washington, DC.

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Activity Number: 340
Type: Invited
Date/Time: Tuesday, August 4, 2009 : 2:00 PM to 3:50 PM
Sponsor: Section on Statistics in Epidemiology
Abstract - #303068
Title: Statistical Issues and Challenges of Epigenomics
Author(s): Rebecca W. Doerge*+
Companies: Purdue University
Address: 150 North University Street, West Lafayette, IN, 47907,
Keywords: epigenomics ; epigenetics ; tiling array ; statistical genomics
Abstract:

Epigenomics is the study of heritable changes in genome function that occur in the absence of changes to the DNA sequence, and is the second-code of instruction that affects gene activity. Although, this change in behavior of DNA is heritable, it is not well understood by the scientific and medical communities. Even though there are similarities in the statistical models that are used to test differential expression, testing for epigenomic modifications is different, and is a good example of when testing the incorrect hypothesis will lead to the wrong conclusion. The statistical issues surrounding the identification of epigenomic changes will be discussed for the purpose of illustrating the differences between testing differential gene expression and epigenomic modifications.

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