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Activity Number:
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196
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Type:
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Invited
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Date/Time:
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Monday, August 3, 2009 : 2:00 PM to 3:50 PM
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Sponsor:
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WNAR
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| Abstract - #303055 |
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Title:
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A Likelihood Approach for Case-Control Family Data
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Author(s):
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Yingye Zheng*+ and Patrick Heagerty
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Companies:
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Fred Hutchinson Cancer Research Center and University of Washington
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Address:
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1100 Fairview Ave, NE , Seattle, WA, 98109,
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Keywords:
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Family study ; Outcome dependent sampling
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Abstract:
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Two complications arise in the genetic association study with family data from retrospective study designs. One issue is that correlations of disease risk often exist among family members. The other issue is that nonrandom ascertainment is commonly used in genetic study of rare disease. The likelihood a family is recruited may depend on the disease outcome information of the family. We describe a likelihood-based method that permits the estimation of effects on disease risk of genes, environmental factors, and gene-environment interactions under study design that includes cases, relatives of cases, and unrelated individuals. The method accommodates family residual correlation and a variety of ascertainment schemes, in particular the retrospective family studies with a two-phase sampling. The method will be illustrated with simulation study and an application to a study of colon cancer.
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- The address information is for the authors that have a + after their name.
- Authors who are presenting talks have a * after their name.
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