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Activity Number: 446
Type: Invited
Date/Time: Wednesday, August 5, 2009 : 10:30 AM to 12:20 PM
Sponsor: Statistics in Biopharmaceutical Research Journal
Abstract - #302971
Title: Adaptive Dose-Finding in Non-Life-Threatening Diseases: Review and Case Studies
Author(s): Anastasia Ivanova*+
Companies: The University of North Carolina at Chapel Hill
Address: Dept. of Biostatistics, CB# 7420, Chapel Hill, NC, 27599,
Keywords: Proof-of-concept trial ; Dose finding ; cross-over design ; isotonic regression
Abstract:

Adaptive designs in dose-finding are now making their way to therapeutic areas other then oncology. Dose-finding trials are good candidates for using adaptive designs because the major emphasis is on estimation, rather than hypothesis testing. We will review various dose finding problems where adaptive dose finding designs can be advantageous and present case studies.

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Revised September, 2008