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Activity Number:
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96
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Type:
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Invited
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Date/Time:
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Monday, August 3, 2009 : 8:30 AM to 10:20 AM
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Sponsor:
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ENAR
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| Abstract - #302888 |
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Title:
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Are Pedigree Data Necessary and Critical in Modern Genomic Studies?
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Author(s):
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Robert C. Elston and Kathleen R. Merikangas*+
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Companies:
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Case Western Reserve University and National Institutes of Health
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Address:
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Building 35, Room 1A-201, Bethesda, MD, 20892-3720,
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Keywords:
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Pedigree Study ; Genome-wide Association Study ; Family Study ; Statistical Genetics
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Abstract:
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Drs. Elston and Merikangas will describe different aspects of genetic studies of unrelated and related individuals. They will compare and contrast the two approaches in terms of statistical power, feasibility, cost and effort. Considerations in this comparison will include strength of the genetic effect, phenotypic and genotypic heterogeneity, and interactive influences of genes and environmental exposures. The application of pedigree data to define phenotypes, intermediate phenotypes and modes of transmission and the use of this information to refine studies of unrelated individuals will be described.
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- The address information is for the authors that have a + after their name.
- Authors who are presenting talks have a * after their name.
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