JSM Preliminary Online Program
This is the preliminary program for the 2009 Joint Statistical Meetings in Washington, DC.

The views expressed here are those of the individual authors
and not necessarily those of the ASA or its board, officers, or staff.

Back to main JSM 2009 Program page

Activity Number: 545
Type: Invited
Date/Time: Thursday, August 6, 2009 : 8:30 AM to 10:20 AM
Sponsor: IMS
Abstract - #302880
Title: Composite Likelihood Estimation for Age-Dependent Branching Processes Using CFSE-Labeling Data
Author(s): Ollivier Hyrien*+ and Rui Chen and Martin S. Zand
Companies: University of Rochester and University of Rochester Medical Center and University of Rochester
Address: 601 Elmwood Avenue, Rochester, NY, 14642,
Keywords: branching processes ; composite likelihood ; dependent data ; cell proliferation ; asymptotic theory
Abstract:

CFSE-labeling experiment has become a standard tool to study the dynamics of cell populations, especially lymphocytes. A number of mathematical models have been proposed to model the temporal development of cell populations during these experiments, but little attention has been given to the statistical issues that arise with such data. In this talk, we will present a composite likelihood approach to estimate cell kinetic parameters from CFSE-labeling data in the context of multitype age-dependent branching processes. Properties of the proposed estimator are investigated using asymptotic theory and simulations. An application to T lymphocytes is presented.

  • The address information is for the authors that have a + after their name.
  • Authors who are presenting talks have a * after their name.

Back to the full JSM 2009 program


JSM 2009 For information, contact jsm@amstat.org or phone (888) 231-3473. If you have questions about the Continuing Education program, please contact the Education Department.
Revised September, 2008