JSM Preliminary Online Program
This is the preliminary program for the 2009 Joint Statistical Meetings in Washington, DC.

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Activity Number: 87
Type: Invited
Date/Time: Monday, August 3, 2009 : 8:30 AM to 10:20 AM
Sponsor: International Chinese Statistical Association
Abstract - #302862
Title: Elucidation of Clinical Trial Intervention Effects Using Genomic and Proteomic Discovery Platforms
Author(s): Ross L. Prentice*+
Companies: Fred Hutchinson Cancer Research Center/University of Washington
Address: 1100 Fairview Ave. N, Seattle, WA, 98109,
Keywords: Genomic ; Proteomic ; Randomized trial ; Hazard ratio ; Multiple testing ; Mediation
Abstract:

The Women's Health Initiative postmenopausal hormone therapy trials demonstrated effects of estrogen plus progestin and estrogen alone on important clinical outcomes, and substantially changed medical practice. Here a high-dimensional SNP platform will be considered to identify subsets of women with relatively favorable benefit versus risk profile, and high-dimensional proteomic platform will be considered to identify biological pathways that help to explain clinical trial intervention effects. Methodologic issues related to platform throughput, multiple testing, and the approach to assessing biomarker changes as mediators of intervention effects, will be briefly discussed.

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