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Activity Number:
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340
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Type:
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Invited
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Date/Time:
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Tuesday, August 4, 2009 : 2:00 PM to 3:50 PM
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Sponsor:
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Section on Statistics in Epidemiology
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| Abstract - #302768 |
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Title:
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Statistical Methods for Differential Diagnosis of Second Primary Cancers from Metastases
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Author(s):
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Colin B. Begg*+
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Companies:
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Memorial Sloan-Kettering Cancer Center
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Address:
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307 East 63rd Street, 3rd Floor, New York, NY, 10065,
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Keywords:
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tumor clonality ; genetic fingerprints ; array CGH
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Abstract:
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In recent years numerous investigators have conducted genetic studies of pairs of tumor specimens from the same patient to determine whether the tumors share a clonal origin. These studies have the potential to be of considerable clinical significance, especially in settings where the distinction of a new primary cancer and metastatic spread of a previous cancer would lead to different indications for treatment. Studies of clonality have typically involved comparison of the patterns of somatic mutations in the tumors at candidate genetic loci to see if the patterns are sufficiently similar to indicate a clonal origin. More recently, investigators have explored the use of array CGH for this purpose. New statistical approaches to this problem will be presented that are suited to each of these types of data, along with the results of studies to examine the validity of the methods.
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