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Activity Number:
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135
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Type:
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Invited
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Date/Time:
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Monday, August 3, 2009 : 10:30 AM to 12:20 PM
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Sponsor:
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ENAR
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| Abstract - #302741 |
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Title:
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A Heterozygote-Homozygote Test of Hardy-Weinberg Equilibrium Using Related Individuals
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Author(s):
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Janet S. Sinsheimer*+ and Jin Zhou and Kenneth Lange and Jeanette Papp
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Companies:
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University of California, Los Angeles and University of California, Los Angeles and University of California, Los Angeles and University of California, Los Angeles
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Address:
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Human Genetics, Los Angeles, CA, 90095,
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Keywords:
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Genetic Equilibrium ; Genetics ; Likelihood Estimation ; Pedigree Analysis
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Abstract:
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The Hardy-Weinberg law remains fundamental to genetics but few tests can be applied to related individuals. Typically Hardy-Weinberg equilibrium (HWE) is tested in unrelated individuals using a one degree of freedom chi-square test that compares expected and observed numbers of heterozygotes and homozygotes. We developed a parsimonious HWE test that can use both pedigree and unrelated individuals. The underlying statistical model depends on a parameter that determines the ratio of heterozygous genotypes to homozygous genotypes among pedigree founders. Because our heterozygous-homozygous (HH) test allows for non-codominant markers, it can be used with several linked single nucleotide polymorphisms without first haplotyping. Our experience on real and simulated data suggests that the HH test has correct type-one error rates and good power when compared to other tests of HWE.
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