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This is the preliminary program for the 2008 Joint Statistical
Meetings in Denver, Colorado.
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The views expressed here are those of the individual authors and not necessarily those of the ASA or its board, officers, or staff. Back to main JSM 2008 Program page |
= Applied Session,
= Theme Session,
= Presenter|
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| CE_33T | Wed, 8/6/08, 10:00 AM - 11:45 AM | HY-Capitol Ballroom 1 |
| EastAdapt: A Module for Late-Stage Adaptive Trial Design Within the East® 5 Software System - Continuing Education - CTW | ||
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ASA |
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| Instructor(s): Cyrus R. Mehta, Cytel Inc. | ||
| We will demonstrate EastAdapt®, a major upgrade of the adaptive design module of East that is used for designing and simulating late-stage (phase II and phase III) clinical trials. EastAdapt makes it possible to design clinical trials with a data-dependent mid-course correction to sample size, spending function, and number of future interim analyses and their spacing without inflating the type I error. EastAdapt's simulations are used to determine the operating characteristics of the adaptive design and compare them to those of a classical group sequential design. A major new capability is the ability to compute valid p-values, point estimates, and confidence intervals at the end of the adaptive clinical trial. Another major new EastAdapt capability is the ACR Method for performing the adaptive hypothesis test. With the ACR method, one can use the usual sufficient statistic, rather than the Cui, Hung and Wang (1999) weighted statistic to determine statistical significance. | ||
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JSM 2008
For information, contact jsm@amstat.org
or phone (888) 231-3473. If you have questions about the Continuing Education program,
please contact the Education Department. |