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Activity Number:
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453
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Type:
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Contributed
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Date/Time:
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Wednesday, August 6, 2008 : 2:00 PM to 3:50 PM
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Sponsor:
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Section on Bayesian Statistical Science
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| Abstract - #302599 |
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Title:
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Bayesian Objective Testing of Hardy-Weinberg Equilibrium
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Author(s):
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Brenda Betancourt*+ and Maria E. Perez
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Companies:
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University of Puerto Rico and University of Puerto Rico
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Address:
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Av Universidad # 4 Torre Norte, San Juan, PR, 00925, Puerto Rico
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Keywords:
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Hardy-Weinberg equilibrium ; Intrinsic Priors ; Hypothesis Testing
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Abstract:
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Assessment of Hardy-Weinberg equilibrium is one of the basic problems in population genetics and it is far for being closed from the statistical point of view, as recent efforts in this direction prove. The selection of prior distributions for testing Hardy-Weinberg equilibrium is a difficult issue, as we are dealing with a low-dimensional null hypothesis. Recent advances in Objective Bayesian Analysis allow the construction of priors specially suited for Bayesian testing (intrinsic priors). In this work, an intrinsic prior for testing Hardy-Weinberg equilibrium is calculated from the uniform prior using training samples as in Casella and Moreno (2006). The prior obtained is a mixture of Dirichlet distributions. An analysis of sensitivity to different sizes of the training samples is shown.
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