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Activity Number:
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486
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Type:
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Contributed
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Date/Time:
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Thursday, August 7, 2008 : 8:30 AM to 10:20 AM
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Sponsor:
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Biometrics Section
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| Abstract - #302485 |
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Title:
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Family-Based Conditional Gene Test
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Author(s):
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Thomas Hoffmann*+ and Nan Laird
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Companies:
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Harvard School of Public Health and Harvard School of Public Health
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Address:
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655 Huntington Ave., Boston, MA, 02115,
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Keywords:
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family-based ; genetics ; association test
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Abstract:
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Consider the situation in which we have a candidate region of interest, in which the markers are in LD, and testing for association of the main effects of some of the markers are significant. We would like to be able to test if one of these markers is the DSL. The effect size is a function of allele frequency and LD, this it is often not enough to simply find the maximum univariate chi-squared test. We introduce a family-based multi-marker conditional gene test to address this question for binary or continuous traits in nuclear families.
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