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Activity Number:
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34
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Type:
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Contributed
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Date/Time:
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Sunday, August 3, 2008 : 2:00 PM to 3:50 PM
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Sponsor:
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Biopharmaceutical Section
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| Abstract - #302409 |
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Title:
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Optimal Ray Design for Drug Combinations
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Author(s):
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Yuehui Wu*+ and John J. Peterson
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Companies:
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GlaxoSmithKline and GlaxoSmithKline Pharmaceuticals
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Address:
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1250 South Collegeville Road, Collegeville, PA, 19426,
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Keywords:
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drug combination ; fixed-ratio ray design ; locally D-optimal design
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Abstract:
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When two drugs are studied as a mixture in the drug development, one expects the combination works better than any of the drugs works alone. To investigate this, we consider the fixed-ratio ray design that the ratio of drug A to drug B is fixed on a single ray for different doses and the observation will be collected on a few rays (ratios) in the whole experiment. The model under consideration is the nonlinear logistic model and the locally D-optimal design techniques will be applied to locate the optimal ray design which answers the following questions: how many rays are needed? What ratios should one chose? How many subjects should be located on each dose? We also consider the D-optimal design under some restrictions such as the total number of rays and the number of different doses on each ray is limited. Comparison of the optimal design to a random selected ray design is also made.
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