|
Activity Number:
|
315
|
|
Type:
|
Contributed
|
|
Date/Time:
|
Tuesday, August 5, 2008 : 2:00 PM to 3:50 PM
|
|
Sponsor:
|
Section on Statistics in Epidemiology
|
| Abstract - #302401 |
|
Title:
|
A Bayesian Method for Inferring Transmission Chains in a Partially Observed Epidemic
|
|
Author(s):
|
Jaideep Ray*+ and Youssef M. Marzouk
|
|
Companies:
|
Sandia National Laboratories and Sandia National Laboratories
|
|
Address:
|
MS 9159, PO Box 969, Livermore, CA, 94550-0969,
|
|
Keywords:
|
Bayesian inference ; transmission chains ; smallpox ; Abakaliki
|
|
Abstract:
|
We present a Bayesian approach for estimating transmission chains and rates in the Abakaliki smallpox epidemic of 1972. The epidemic affected 30 individuals in a community of 74; only the dates of appearance of symptoms were recorded. Our model assumes stochastic transmission of the infections over a social network. Distinct binomial random graphs model intra- and inter-compound social connections, while disease transmission over each link is treated as a Poisson process. Link probabilities and rate parameters are objects of inference. Dates of infection and recovery comprise the remaining unknowns. Distributions for smallpox incubation and recovery periods are obtained from historical data. Using Markov chain Monte Carlo, we explore the joint posterior distribution of the scalar parameters and provide an expected connectivity pattern for the social graph and infection pathway.
|
