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Activity Number:
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520
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Type:
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Contributed
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Date/Time:
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Thursday, August 7, 2008 : 10:30 AM to 12:20 PM
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Sponsor:
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Biometrics Section
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| Abstract - #302373 |
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Title:
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Analysis of Arabidopsis Genome Tiling Arrays To Detect Nuclear Pre-mRNA Processing Events and Differential Gene Expression
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Author(s):
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Ann Hess*+ and Amber Hackstadt and A.S.N. Reddy and Arthur Hunt
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Companies:
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Colorado State University and Colorado State University and Colorado State University and University of Kentucky
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Address:
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1877 - Department of Statistics, Fort Collins, CO, 80523,
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Keywords:
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microarrays ; alternative splicing
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Abstract:
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Nuclear pre-mRNA processing events, especially alternative splicing and alternative polyadenylation of pre-mRNAs, are important regulators of gene expression. These processes generate multiple transcripts from a single gene and thereby contribute greatly to transcriptome complexity and gene regulation in eukaryotic organisms. Genome tiling arrays offer an unprecedented opportunity to investigate these processes on a global scale. Here we discuss some progress and challenges in analyzing Arabidopsis tiling array data to detect alternative splicing as well as differential gene expression. Analysis of tiling array data for these purposes is largely unexplored and requires novel approaches. Our approach uses the mixed model framework.
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