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Abstract:
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In a randomized study of Type-2 diabetes mellitus, we hypothesized: 1) Weight loss is associated with reduction in markers of vascular inflammation (CRP, IL6), and 2) this relationship is influenced by insulin sensitivity and glycemic control (A1c). Mixed model for longitudinal repeated measures data was used. Month effect (baseline, 2, 6, and 12 months) is expressed through within subject variation. Two-response multivariate model was run and the results were compared to that of separate models. Residual plots and influential analysis were provided for model validation. Bivariate regression model gave similar results as two separate models for CRP and IL6. Weight loss is significantly associated with reduction of CRP, but not with IL6. The amount of reduction in CRP, however, depends on a1c. The higher the a1c is, the less the reduction will be.
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