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Abstract:
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For detection of early diseases, single biomarkers are often lacking sensitivity and/or specificity to discriminate between diseased and non-diseased populations. Therefore, diagnostic industry pays more attention to the search and development of biomarker panels instead of a single marker. Challenges are (amongst others): to establish strategies for biomarker search, to provide qualified classification and feature selection methods for picking up the best biomarker combination, and to validate biomarker panels. By discussion of concrete examples, we show for small panels of proteomics markers possible solutions for the different steps of the process of marker panel selection and evaluation.
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