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Activity Number:
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404
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Type:
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Contributed
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Date/Time:
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Wednesday, August 6, 2008 : 10:30 AM to 12:20 PM
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Sponsor:
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Biopharmaceutical Section
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| Abstract - #301720 |
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Title:
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Optimal Allocation Ratio in Multiple-To-One Comparison Trials
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Author(s):
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Jianliang Zhang*+
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Companies:
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MedImmune, Inc.
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Address:
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One Medimmune Way, Gaithersburg, MD, 20878,
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Keywords:
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multiple-to-one comparison ; optimal allocation ratio ; multivalent vaccine ; unequal variance
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Abstract:
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This paper discusses multiple-to-one comparison trials testing a multivalent vaccine product against multiple comparators with respect to immunological responses. An optimal subject allocation ratio between the multivalent vaccine group and any of the comparators is introduced. This optimal ratio leads to higher statistical efficiency in terms of savings in sample size compared to equal allocation or any other allocation ratios. Several trial design scenarios are considered in the paper including assumptions of equal variance, unequal variance and unequal standardized effect sizes of the multivalent vaccines verses the multiple comparators.
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- The address information is for the authors that have a + after their name.
- Authors who are presenting talks have a * after their name.
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