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Activity Number:
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232
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Type:
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Contributed
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Date/Time:
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Tuesday, August 5, 2008 : 8:30 AM to 10:20 AM
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Sponsor:
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Section on Statistics and the Environment
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| Abstract - #301664 |
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Title:
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Reconstruction of General Population Exposure to Perchloroethylene with Sparse Biomonitoring Data
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Author(s):
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Junshan Qiu*+
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Companies:
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The University of Georgia
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Address:
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101 Cedar Street, Athens, GA, 30602,
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Keywords:
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Exposure reconstruction ; Biomonitoring ; PBPK ; Bayesian
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Abstract:
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Physiologically based pharmacokinetics (PBPK) models have been extensively used to predict tissue dosimetry under controlled exposure conditions. Using biomonitoring data to reconstruct exposure profile with PBPK model is challenging. But the distributions of exposures or possible exposure pattern can be estimated based on the survey information of human activity diary or incomplete information of exposure. In this paper, we developed a method used to construct exposure concentration time profile of PCE for general population based on the biomonitoring data available. The distributions of exposure parameters are derived based on biomonitoring data or previous survey studies of human activity. Posterior distributions of model parameters were used to conduct Monte Carlo (MC) simulations. Bootstrap resampling was used to capture uncertainty of exposure conditions based on MC results.
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