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Activity Number: 184
Type: Topic Contributed
Date/Time: Monday, August 4, 2008 : 2:00 PM to 3:50 PM
Sponsor: WNAR
Abstract - #301524
Title: Evaluation Process of Imaging Biomarker: Quantitative Lung Fibrosis (QLF) Score for Computer Tomography (CT) Data in Interstitial Lung Disease
Author(s): Hyun Jung (Grace) Kim*+ and Gang Li
Companies: University of California, Los Angeles and University of California, Los Angeles
Address: 924 Westwood Blvd ste 650, Los Angeles, CA, 90024,
Keywords: Biomarker ; Interstitial Lung Disease ; CT ; Denoise ; Classification ; image
Abstract:

Imaging modality can vividly show the treatment efficacy in therapeutic intervention. We need to develop and evaluate the vocabulary, imaging biomarker, for the treatment efficacy. The important factors in biomarker evaluation are calibration, discrimination and accuracy in multicenter clinical trial. To be qualified for imaging surrogates biomarker, many challenges are present in the calibration before applying to clinical trial and research application, because different technical factors create a different level of noise and affect to the measurement of imaging biomarker. We present a novel QLF, "biomarker," of CT imaging: denoise as part of calibration and comparison of radiologist score with QLF as discrimination and accuracy. We, then, show this imaging "biomarker," QLF, as outcome variable for the treatment efficacy in the proven scleroderma-lung-disease clinical trial.

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Revised September, 2008