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Abstract:
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In environmental samples, bioassays are usually used to evaluate the potency of an agency contained in the sample on living organisms, such as insects or rats. Similar to the bioanalytical methods, the limit of detection is a measure of the sensitivity of the method. Bioassay uses a standard curve over a series of concentrations for inversely predicting the concentration level in the test sample. Similar to bioanalytical assay, the results are usually affected by some additional random factors which in this case are due to the characteristics of the living organism, such as variation among batches or the fit of the response curve over the concentration levels. In this study, we examine the effect that these additional random factors have on the estimation of the limit of detection.
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