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Activity Number:
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242
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Type:
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Contributed
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Date/Time:
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Tuesday, August 5, 2008 : 8:30 AM to 10:20 AM
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Sponsor:
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Biometrics Section
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| Abstract - #301383 |
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Title:
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Discovery of Novel Protein Domains: The Parasitic Connection
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Author(s):
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Ian Lee*+
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Companies:
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National University Hospital
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Address:
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Department of Haematology-Oncology, Singapore, International, 119074, Singapore
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Keywords:
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HMM ; Gibbs Sampler ; Convergence ; Parasites
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Abstract:
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Domains are key indicators of protein function. While statistical models based on iterated profile searches (PSIBLAST) have been instrumental in their detection, they face certain limitations. Convergence is hampered by inclusion of closely-related sequences that limit the scope of the model or insufficient signal strength to detect distant relationships. Recent large-scale sequencing of parasite genomes provides a means of alleviating this problem. Using sequences from the malaria and trypanosome genomes as bridging points in model construction, we have previously identified the RAP and SMP domains (Lee and Hong 2004, 2006). We further illustrate this with identification of a novel domain through the use of another sequenced parasite genome: Entamoeba histolytica. The domain is amplified in this species and other microbes and is of potential relevance for human pathology.
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- The address information is for the authors that have a + after their name.
- Authors who are presenting talks have a * after their name.
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