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Activity Number:
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242
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Type:
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Contributed
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Date/Time:
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Tuesday, August 5, 2008 : 8:30 AM to 10:20 AM
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Sponsor:
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Section on Statistics in Epidemiology
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| Abstract - #301251 |
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Title:
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Individualized Absolute Risks from Epidemiologic Data
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Author(s):
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Anne S. Reiner*+ and Colin B. Begg and Elyn Riedel and Marinela Capanu and Jonine Bernstein
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Companies:
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Memorial Sloan-Kettering Cancer Center and Memorial Sloan-Kettering Cancer Center and Memorial Sloan-Kettering Cancer Center and Memorial Sloan-Kettering Cancer Center and Memorial Sloan-Kettering Cancer Center
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Address:
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307 East 63rd Street, New York, NY, 10065,
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Keywords:
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absolute risk ; contralateral ; breast cancer ; epidemiology
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Abstract:
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Relative risks in epidemiologic studies do not always have the clinical utility of individual absolute risks, which can be derived from epidemiologic data. The Women's Environmental Cancer and Radiation Epidemiology (WECARE) study has a unique design, where controls are women with unilateral breast cancer and cases are women with contralateral breast cancer (CBC). We calculate absolute risk of developing CBC by combining relative risks from a conditional logistic model from WECARE with baseline age-specific CBC rates from the general population using Surveillance Epidemiology and End Results (SEER) data. This method projects individualized risk estimates of developing CBC over a span of time and across a constellation of risk factors. This example highlights the method's clinical relevance, as women who survive a first primary breast cancer are at risk for CBC.
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