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Activity Number: 449
Type: Contributed
Date/Time: Wednesday, August 6, 2008 : 2:00 PM to 3:50 PM
Sponsor: Biometrics Section
Abstract - #301176
Title: A General Framework for Bilevel Variable Selection
Author(s): Patrick Breheny*+ and Jian Huang+
Companies: The University of Iowa and The University of Iowa
Address: , , , , , ,
Keywords: Lasso ; Penalized Regression ; Group lasso ; SCAD ; Variable Selection ; Group bridge
Abstract:

Penalized methods are very useful in sparse regression problems. In many applications, variables have a grouping structure that can be incorporated into the penalty. Here, we introduce a general framework that allows penalties such as ridge, lasso, and SCAD to be combined independently at the group and individual levels, and present algorithms to fit these models. This framework incorporates two existing approaches, group bridge and group lasso. The proposed methods are capable of simultaneous selection at the group and individual variable levels and can be applied to linear and general regression models. Simulations indicate that these group approaches are superior to penalties that ignore grouping structures and provide insight into choosing penalties that best reflect study goals. Finally, we apply these approaches to a genetic association study of age-related macular degeneration.


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