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Activity Number:
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513
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Type:
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Contributed
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Date/Time:
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Thursday, August 7, 2008 : 10:30 AM to 12:20 PM
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Sponsor:
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Section on Statistics in Epidemiology
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| Abstract - #301100 |
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Title:
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A Variance Components Method To Test for QTL Heterogeneity Among Multiple Ethnic Groups
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Author(s):
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Trecia A. Kippola*+ and Karen L. Edwards and Stephanie A. Monks
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Companies:
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Oklahoma State University and University of Washington and Oklahoma State University
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Address:
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MSCS 301, Stillwater, OK, 74078,
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Keywords:
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heterogeneity ; variance components ; QTL analysis ; multiple ethnic groups ; metabolic syndrome
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Abstract:
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Numerous methods exist for conducting linkage analysis for a quantitative trait locus (QTL); however, these methods do not allow for heterogeneity that may arise when testing for linkage using multiple families from different ethnic groups, countries or geographic locations. We propose a method, which is an extension of the variance components method suggested by Almasy and Blangero (1998). Our method can determine if there exists statistically significant linkage while allowing for heterogeneity among different ethnic groups, countries or geographic locations. We also propose a test for determining if heterogeneity exists. Both tests are based on likelihood ratio test statistics and will be applied to an existing data set consisting of genotype and metabolic syndrome phenotype data. Simulation results of various statistical properties, of our proposed methods will be presented.
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