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Activity Number:
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366
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Type:
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Contributed
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Date/Time:
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Wednesday, August 6, 2008 : 8:30 AM to 10:20 AM
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Sponsor:
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Biopharmaceutical Section
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| Abstract - #300950 |
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Title:
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Clinical Trial Monitoring with Bayesian Hypothesis Testing
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Author(s):
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John D. Cook*+
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Companies:
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The University of Texas M.D. Anderson Cancer Center
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Address:
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1515 Holcombe Blvd, Houston, TX, 77030,
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Keywords:
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trial monitoring ; Bayesian ; hypothesis testing
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Abstract:
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Bayesian methods for sequential monitoring of clinical trials are often based on random inequalities. We present an alternative approach based on hypothesis testing with nonlocal priors. The test-based methods appear to have better operating characteristics than their inequality-based counterparts, based on asymptotic properties for large samples and simulation studies for small samples.
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