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Activity Number:
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404
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Type:
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Contributed
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Date/Time:
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Wednesday, August 6, 2008 : 10:30 AM to 12:20 PM
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Sponsor:
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Biopharmaceutical Section
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| Abstract - #300936 |
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Title:
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Sample Size Calculation for an Agreement Study
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Author(s):
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Jason Liao*+
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Companies:
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Merck Research Laboratories
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Address:
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P.O.Box 4, West Point, PA, 19486,
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Keywords:
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Concordance ; Agreement interval ; Sample size ; Discordance rate ; Tolerance probability
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Abstract:
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It is often necessary to compare two measurement methods in medicine and other experimental sciences. This problem covers a broad range of data. Many authors have explored ways of assessing the agreement of two sets of measurements. However, there has been relatively few attention to the problem of determining sample size for designing an agreement study. In this paper, a method using the interval approach for concordance is proposed to calculate sample size in conducting an agreement study. The sample size calculation is based on two rates: the discordance rate and tolerance probability, which in turn can be used to quantify an agreement study. The proposed approach is demonstrated through a real data set.
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