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Activity Number:
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180
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Type:
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Topic Contributed
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Date/Time:
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Monday, August 4, 2008 : 2:00 PM to 3:50 PM
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Sponsor:
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Section on Risk Analysis
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| Abstract - #300796 |
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Title:
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Low-Dose Extrapolation from Points of Departure or from Model-Averaged Estimates
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Author(s):
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A. John Bailer*+ and Matthew Wheeler
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Companies:
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Miami University and Centers for Disease Control and Prevention
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Address:
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Dept. of Math. & Stat., Oxford, OH, 45056,
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Keywords:
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risk estimation ; benchmark doses
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Abstract:
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Experiments with relatively high dose conditions are often used to predict risks at appreciably lower doses. A point of departure can be calculated as the dose associated with a moderate response level (e.g. benchmark dose associated with a benchmark response of 10%). A linear extrapolation to lower doses can then follow. This method is compared to the use of model-averaged predictions in the context of a number of animal bioassay experiments.
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